Research

Thesis

Master of Surgery Thesis
The Institute of Cancer Research, London University

My thesis was researched at The Institute of Cancer Research, The Royal Marsden Hospital and Mayday University Hospital. The thesis examined the interaction between CD44 and the enzymes matrix metalloproteinases, which have an important action in the development of metastasis and angiogenesis in colorectal cancer. It was a study looking at changes occurring during colorectal cancer disease progression and measuring blood factors as a predictor of disease stage and response to chemoradiotherapy. Experiments were also performed to change gene expression in colorectal cancer cells to alter the metastatic ability of cancer cells. Work form this project was presented at The Surgical Research Society; The Association of Surgeons of Great Britain and Ireland; The Association of Coloproctology; The European Association of Coloproctology; Digestive Disease Week, USA and at other national and international meetings, and as original papers.

Book Chapters

1. Laparoscopic repair of groin and other abdominal wall hernias
   J. M. Wellwood & M. G. Tutton
   R.M. Kirk, General Surgical Operations, 5th Edition, 2006, Churchill Livingstone
2. Laparoscopic repair of groin hernias.
   J. M. Wellwood & M. G. Tutton
   Kirk and Winslet, Essential General Surgical Operations. 2nd Edition, 2007, Churchill Livingstone.

Publications

1. Day case laparoscopic incisional hernia repair is feasible, acceptable and cost effective.
   A.H Engledow, N. Sengupta, D. Francis, M.G Tutton, S.J Warren
   Surgical Endoscopy 2007; 21(1), 84-86.
2. Use of plasma MMP-2 and MMP-9 levels as a surrogate for tumour expression in colorectal cancer patients.
   M.G.Tutton, M.L.George, S.A.Eccles, S.Burton, R.I.Swift, A.M.Abulafi
   International Journal of Cancer 2003; 107: 541-550.
3. Colonoscopy in the elderly: safe and sound practice
   ML George, MG Tutton, VV Jadhav, AM Abulafi, RI Swift
   Age and Aging 2002 Jan;31(1):80-1.
4. Plasma basic fibroblast growth factor levels in colorectal cancer: a clinically useful assay?
   ML George, MG Tutton, MA Abulafi, SA Eccles and RI Swift
   Clinical Experimental Metastasis. 2002;19(8):735-8.
5. Discomfort with fine-needle aspiration cytology of the breast.
   M.G.Tutton, N.M.Aqel, D.St J. Collier
   Lancet 2001; 357(9258): 804-5.
6. Solitary pancreatic metastasis from a primary colorectal tumour detected by PET scan: report of a case
   M.G.Tutton, M.George, M.Hill, A.M.Abulafi
   Disease of colon and Rectum 2001; 44(2): 288-90.
7. VEGF A, C and D in colorectal cancer progression
   ML George, MG Tutton, F Janssen, A Arnaout, A M Abulafi, SA Eccles, RI Swift
   Neoplasia 2001, 3(5): 420-427
8. Screwdriver Assaults and Intracranial Injuries.
   M.G.Tutton, B.Chitnavis, I.Stell
   Journal of Accident and Emergency Medicine 2000; 17(3): 225-226.
9. Correspondence
   ML George, SA Eccles, G Box, MG Tutton, AM Abulafi, RI Swift
   Clinical Cancer Research 2001; 7 (2): 444
10. Reply.
    ML George, SA Eccles, G Box, M Tutton, AM Abulafi, RI Swift.
    Clinical Cancer Research 2001; 7(5): 1483
11. Correlation of plasma and serum vascular endothelial growth factor (VEGF) with platelet count in colorectal cancer: clinical evidence of platelet scavenging.
    ML George, SA Eccles, M Tutton, MA Abulafi and RI Swift.
    Clinical Cancer Research 2000; 6(8): 3147-52.
12. Morphology of oligodendrocytes during demyelination in optic nerves of mice infected with Semliki Forest virus.
    Butt A.M, Tutton M.G, Kirvell S.L, Amor S. Jenkins HG .
    Neuropathology & Applied Neurobiology 1996; 22(6):540-547.
13. Three-dimensional morphology of astrocytes and oligodendrocytes in the intact mouse optic nerve.
    Butt, Colquhoun, Tutton, Berry
    Journal of Neurocytology 1994; 23: 469-485.
14. Response of oligodendrocytes to glutamate and y-aminobutyric acid in the intact mouse optic nerve.
    A.Butt & M.G.Tutton Neuroscience Letters 1992; 146: 108-110.

Presented Abstracts

1. Missed Injuries in a District General Hospital: The Need for a Tertiary Survey.
   N Pawa, C Cruise, AMC Goodson, MG Tutton, International College of Surgeons, Austria, December 2008
2. Failure to Prevent Venous Thromboembolism in Surgical Patients Incurs Significant Negligence Costs in NHS Hospitals.
   M Ypsilantis, N Pawa, MG Tutton. International College of Surgeons, Austria, December 2008
3. The impact of MMC on sick leave in a district general hospital.
   N Pawa, MG Tutton. BMA-AMA-CMA International Conference, London, November 2008.
4. The new consultant colorectal surgeon: An emergency safe surgeon?
   M Ypsilantis, N Pawa, MG Tutton, European Soceity of Coloproctology, Nantes, France, September 2008.
5. Laparoscopy for Sepsis Secondary to Post-Operative Ileus.
   N Pawa, MG Tutton. European Association of Endoscopic Surgeons, Stockholm, Sweden, June 2008.
6. Is the Barium Enema a Cost Effective Study?
   N Pawa, MG Tutton. Association of Coloproctology, Birmingham, June 2008.
7. Is the Barium Enema an Outdated Study?
   N Pawa, MG Tutton. American Society of Colorectal Surgeons, Boston, June 2008.
8. Delay in Diagnosis of Appendicitis – Trends in Litigation in the U.K
   N.Pawa, R.Nouri, MG Tutton, European Society for Surgical Research, Warsaw, Poland, May 2008.
9. The introduction of pre-printed admission booklets as a method of improving the completeness of clinical admission documentation in an acute surgical unit.
   M Ypsilantis, N Pawa, MG Tutton, International Forum on Quality and Safety in Health Care, Paris, April 2008.
10. Laparoscopic Common Bile Duct Exploration Performed by Trainees.
    N Pawa, MG Tutton, RW Motson. Association of Surgeons In Training, Birmingham, March 2008 .
11. Laparoscopic Total Colectomy – A UK Experience.
    N Pawa, MG Tutton, RW Motson. ICLCRS, Florida, February 2008.
12. Reduced inpatient stays with the uptake of laparoscopic appendicectomy over a ten year period at a district general hospital.
    Z Hirmiz, GJK Tiwari, D Ismail, MG Tutton. Association of Laparoscopic Surgeons, November 2007.
13. Does laparoscopic hernia repair impact on basic surgical training?
    GJK Tawari, Z Hirmiz, D Ismail, MG Tutton. Association of Laparoscopic Surgeons, November 2007.
14. Laparoscopic versus open repair of perforated peptic ulcer: A retrospective review of outcomes in a district general hospital.
    N Pawa, E Ypsilantis, MG Tutton, RW Motson. Association of Laparoscopic Surgeons, November 2007.
15. Good completion rates and enhanced safety are achieved by reducing sedation during colonoscopy
    S Venkateshan, M G Tutton. European Association for Endoscopic Surgery. July 2007, Athens.
16. The action of EGFR on prognostic factors in colorectal cancer is an early event in the adenoma-carcinoma sequence.
    M G Tutton, M George, SA Eccles, A.M Abulafi Association of Coloproctology, July 2007, Glasgow. Colorectal Disease 2007; 9(S1): 22.
17. Reducing sedation during colonoscopy improves safety without compromising completion rates.
    S Venkateshan, M G Tutton. Association of Coloproctology, July 2007, Glasgow. Colorectal Disease 2007; 9(S1): 40.
18. Laparoscopic common bile duct exploration can be safely performed by trainees.
    M G Tutton, T Arulampalam, R W Motson. SAGES, April 2007, Las Vegas, USA. Surgical Endoscopy 2007; 21(S1):340-351.
19. Do National Guidelines for Colorectal Polyp Surveillance Safely Predict Subsequent Colorectal Polyp Formation?
    M G Tutton, M Sultana, M Mallik, A H Engledow & S J Warren. European Society of Coloproctology, September 2006, Lisbon. Colorectal Disease 2006; (S), 32
20. Can the Nature of Colorectal Polyps be Predicted by Presenting Symptoms?
    M G Tutton, M Sultana, M Malik, A H Engledow & A J Warren. European Society of Coloproctology, September 2006, Lisbon. Colorectal Disease 2006; (S), 32
21. 18F-FDG PETCT in the Pre-Operative Management of Colorectal Liver Metastases (CRLM)
    A H Engledow, F Pakzad, M Tutton, I Taylor, P Ell. European Society of Coloproctology, September 2006, Lisbon. Colorectal Disease 2006; (S), 27.
22. Can the Use of PETCT in the Management of Colorectal Liver Metastases (CRLM) be Rationalised Using a Validated Clinical Risk Score?
    A H Engledow, F Pakzad, M Tutton, I Taylor & P Ell. European Society of Coloproctology, September 2006, Lisbon. Colorectal Disease 2006; (S), 27.
23. Analysis of the Normal Distribution of FDG in the Lower GI Tract Using PET and the Effect of Oral Contrast.
    A H Engledow, M Gomes, M Tutton & P Ell. European Society of Coloproctology, September 2006, Lisbon. Colorectal Disease 2006; (S), 27.
24. Laparoscopic Learning Curves.
    AH Engledow ,VJ Tidman ,SM Thomas ,MG Tutton ,SJ Warren. World Congress of Endoscopic Surgery, September 2006, Berlin. Surgical Endoscopy 2007; 21(S1): 107-255.
25. Expression Of CD44v3,8-10 Is Prognostic In Colorectal Cancer.
    MG Tutton, M George, SA Eccles, A.M Abulafi Association of Coloproctology, July 2006, Gateshead. Colorectal Disease 2006; 8(S2): 67.
26. Changes In Soluble CD44std Differentiate Between Responders And Non-Responders To Neoadjuvant Chemoradiotherapy In Colorectal Cancer.
    MG Tutton, M George, SA Eccles, A.M Abulafi
    Association of Coloproctology, July 2006, Gateshead. Colorectal Disease 2006; 8(S2): 70.
27. Survival Of Colorectal Cancer Patients In Relation To Gelatinase And Matrilysin Expression.
    M.G.Tutton, S.P.Sharif, M.George, S.Eccles, A.M.Abulafi
    Association of Coloproctology, July 2006, Gateshead. Colorectal Disease 2006; 8(S2): 51
28. Risk Stratification of Colonic Polyps Predicts the Frequency of Further Polyps but not the Degree of Dysplasia.
    M.G Tutton, M Sultana, M Mallik, A.H Engledow, S.J Warren
    Association of Surgeons of Great Britain and Ireland, May 2006, Edinburgh. British Journal of Surgery 2006; 93(S1): 24.
29. Bleeding Polyps are the Worrisome Ones
    M.G Tutton, M Sultana, M Mallik, A.H Engledow, S.J Warren
    Association of Surgeons of Great Britain and Ireland, May 2006, Edinburgh. British Journal of Surgery 2006; 93(S1): 31.
30. Teaching of surgical anatomy: are today’s junior surgeons architects without blueprints?
    S.P.Sharif, M.G.Tutton, G.K Bankani, P.W.W Tan, S.J Snooks
    Association of Surgeons of Great Britain and Ireland, May 2006, Edinburgh. British Journal of Surgery 2006; 93(S1): 47
31. Laparoscopic training. Is routine intraoperative cholangiography a missed opportunity?
    A.H Engledow, J Wright, M.G Tutton, R.W Motson, S.J Warren
    Association of Surgeons in Training. March 2006, Edinburgh
32. Laparoscopic appendicectomy is safe and effective when performed by trainees.
    A.H Engledow, J Wright, M.G Tutton, A.D Jenkinson, R.W Motson, S.J Warren
    Association of Surgeons in Training. March 2006, Edinburgh
33. Pre-operative plasma MMP-2 expression is prognostic in colorectal cancer.
    M.G.Tutton, S.P.Sharif, M.George, S.Eccles, A.M.Abulafi
    Royal Society of Medicine, November 2005, London. Colorectal Disease 2006; 8, 722.
34. Laparoscopic Mesh Repair of Incisional Hernia is More Cost Effective Than the Open Approach.
    Akhras F, Tutton MG, Sengupta N, Thomas S, Engledow A, Warren SJ
    Association of Laparoscopic Surgeons, November 2005, Galway. Surgical Endoscopy 2006; 20(S1)
35. Double contrast barium enema – the correct investigation of lower gastrointestinal symptoms in patients aged 80 years or more?
    A H Engledow, C Allison, I Hadjimichael, R Wellesley, M Tutton, S J Warren
    British Geriatrics Society, October 2005, Harrogate. Age and Aging 2006; 35(S1).
36. Colonoscopic surveillance for high and low risk colorectal polyps. Do national guidelines change practice?
    M.G.Tutton; M.Sultana; A.H.Engledow; S.J.Warren
    European Association of Coloproctology, Sept 2005, Bologna, Colorectal Disease 2005; 7(S2)
37. Investigations of lower gastrointestinal symptoms in patients over 80 years or more – are we getting it right?
    A H Engledow, C Allison, I Hadjimichael, R Wellesley, M Tutton, S J Warren
    European Association of Coloproctology, Sept 2005, Bologna, Colorectal Disease 2005; 7(S2)
38. Is Routine Laparoscopic Intra-operative cholangiography justified?
    M.G.Tutton, N.Sengupta, A.Engledow, S.Warren
    European Association for Endoscopic Surgery, June 2005, Venice. Surgical Endoscopy 2006; 20(S1)
39. District General Hospital Day Case Laparoscopic Mesh Repair of Large Incisional Hernias
    N.Sengupta, D.Francis, A.Engledow, M.G.Tutton, S.Warren
    European Association for Endoscopic Surgery, June 2005, Venice. Surgical Endoscopy 2006; 20(S1)
40. Use of tissue adhesive in closure of thyroidectomy and parathyroidectomy wounds.
    MG Tutton, G Gillan, F Khan, SP Sharif, M Saharay
    European Society of Endocrine Surgeons May 2004, Pisa. Langerbecks Arch Surg 2004; 389: 317
41. Low incidence of recurrent laryngeal nerve injury during thyroid and parathyroid surgery by precise anatomical dissection.
    MG Tutton, G Gillan, F Khan, SP Sharif, M Saharay
    European Society of Endocrine Surgeons May 2004, Pisa. Langerbecks Arch Surg 2004; 389: 317
42. Partial Anal Sphincter Defects from Open Haemorrhoidectomy.
    MG Tutton, A Sultan, T Raymond, AM Abulafi
    Association of Coloproctology, July 2002, Manchester. Colorectal Disease 2002; 4(S1): 68
43. Role of the Colorectal Multidisciplinary Team Meeting.
    MG Tutton, S Mehta, J Lealand, MJ Dworkin
    Association of Coloproctology, July 2002, Manchester. Colorectal Disease 2002; 4(S1): 62
44. Gelatinase A (MMP-2) Expression is a Marker of Invasion in Colorectal Cancer.
    MG Tutton, M George, SA Eccles, I Swift, A.M Abulafi
    Association of Coloproctology, June 2001, Harrogate. Colorectal Disease 2001; 3(S1): 11
45. The Use of local anaesthesia before fine needle aspiration (FNA) of breast lesions
    M.G.Tutton, NM Aqel, DSt J Collier
    Benign Breast Disease, June 2001, London. Breast 2001
46. Use of CD44 Variant 3 Isoforms as a Non-Invasive Investigation for Colorectal Cancer and Adenomatous Polyps.
    MG Tutton, M George, SA Eccles, I Swift, A.M Abulafi
    Digestive Disease Week, May 2001, Atlanta USA. Gastroenterology 2001; 120(5) S1: A36
47. Use of Plasma MMP-2 to Measure Response to Surgery and Chemoradiotherapy in Colorectal Cancer.
    MG Tutton, M George, SA Eccles, I Swift, A.M Abulafi
    Digestive Disease Week, May 2001, Atlanta USA. Gastroenterology 2001; 120(5) S1: A159
48. Expression of CD44v3,8-10 is an early event in progression of colorectal cancer.
    MG Tutton, M George, SA Eccles, I Swift, A.M Abulafi
    European Association of Coloproctology, Sept 2000; Versailles, France.
49. Association of c-erb B receptor tyrosine kinases with VEGF and gelatinases in colorectal cancer progression.
    MG Tutton, M George, SA Eccles, I Swift, A.M Abulafi
    Metastasis Research Society, Sept 2000, London. Clinical and Experimental Metastasis 2000; 17(9): 773
50. Increased expression of CD44 splice variants containing the variable exons v3,8-10 in colorectal cancer and metastases
    MG Tutton, M George, SA Eccles, I Swift, A.M Abulafi
    Metastasis Research Society, Sept 2000, London. Clinical and Experimental Metastasis 2000; 17(9): 786
51. CD44v3,8-10 in progression of colorectal cancer, and serum levels as a measure of tumour expression.
    M.G.Tutton, M.George, S.Eccles, I.Swift, A.M.Abulafi
    Cancer 2000; 83(S1): 19
52. Changes in Plasma Matrix Metalloproteinases 2 and 9 with Dukes Stage and Metastasis in Colorectal Cancer.
    M.G.Tutton, M.George, S.Eccles, I.Swift, A.M.Abulafi
    Association of Coloproctology, July 2000, Brighton. Colorectal Disease 2000; 2(S1): 37
53. Comparison of Positron Emission Tomography with Computed Tomography and Magnetic Resonance Imaging in the Detection of Recurrent and Metastatic Colorectal Cancer.
    M.G.Tutton, M.George, S.Haine, D.Cunningham, M.Hill, A.M.Abulafi
    Association of Coloproctology, July 2000, Brighton. Colorectal Disease 2000 ; 2(S1): 35
54. Audit of Patients Undergoing Three-pedicle haemorrhoidectomy.
    M.G.Tutton, A.M.Abulafi
    Association of Coloproctology, July 2000, Brighton. Colorectal Disease 2000; 2(S1): 61
55. Anal Sphincter Defects in Women with Rectocoele Demonstrated by Endoanal Ultrasound.
    M.G.Tutton, A.Sultan, I.Swift, A.M.Abulafi
    Association of Coloproctology, July 2000, Brighton. Colorectal Disease 2000; 2(S1): 54
56. Relationship of Cleveland Score to Anal Manometry and Endoanal Ultrasound.
    M.G.Tutton, R.Addison, A.Sultan, I.Swift, A.M.Abulafi
    Association of Coloproctology, July 2000, Brighton. Colorectal Disease 2000; 2(S1): 54
57. Colorectal Tumour Progression is Associated with Increased Expression of Matrix Metalloproteinases within Tumour and Plasma.
    M.G.Tutton, M.George, S.Eccles, I.Swift, A.M.Abulafi
    Surgical Research Society, May 2000, Cardiff. British Journal of Surgery 2000; 87(S1): 19
58. The Role of Positron Emission Tomography in Detection of Recurrent and Metastatic Colorectal Cancer.
    M.G.Tutton, M.George, S.Haine, D.Cunningham, M.Hill, A.M.Abulafi
    Association of Surgeons of Great Britain and Ireland, May 2000, Cardiff. British Journal of Surgery 2000; 87(S1): 72.
59. Elevation of basic fibroblast growth factor (bFGF) in plasma occurs late in the adenoma-carcinoma sequence in colorectal malignancy.
    ML George, MG Tutton, AM Abulafi , SA Eccles and RI Swift.
    Metastasis Research Society, Sept 2000, London. Clinical and Experimental Metastasis 2000; 17(9): 785
60. Expression of VEGF-C, VEGF-D and VEGFR-3 mRNA does not correlate with lymphatic spread in colorectal cancer.
    ML George, MG Tutton, F Jansen , SA Eccles and RI Swift.
    Metastasis Research Society, Sept 2000, London. Clinical and Experimental. Metastasis 2000; 17(9): 784
61. Correlation of Plasma and Serum Vascular Endothelial Growth Factor (VEGF) with Platelet Count in Colorectal Cancer (CRC): Clinical Evidence of Platelet Scavenging
    M.George, M.G.Tutton, A.M.Abulafi, S.Eccles, I.Swift,
    Surgical Research Society, May 2000, Cardiff. British Journal of Surgery 2000; 87(S1): 18
62. Colonoscopy in the over 80.
    George M, Tutton MG, Abulafi AM, Swift I
    Association of Coloproctology, June 1999, Southport. Colorectal Disease 1999; 1(S1): 38-39.
63. Response of identified astrocytes and oligodendrocytes to glutamate and GABA in the isolated intact mouse optic nerve.
    M.G.Tutton & A.M.Butt
    Physiological Society, July 1992, Cambridge. Journal of Physiology 1993; 459: 471P
64. Glial response to glutamate and GABA in the isolated mouse optic nerve.
    A.M.Butt & M.G.Tutton
    Society for Neuroscience, October 1992, Anaheim USA. Journal of Neuroscience 1992; 18(S)